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Internal Medicine: December 2016 Updates

Grants

  • Gianfranco Alpini and Dr. Fanyin Meng in collaboration with the Baylor Research Institute and TGen Marketing and Communications Department got a grant from BSW  of $464,390 per a total of 2 years entitled “Genomics Enabled Medicine for Cholangiocarcinoma” with a start date of January 16, 2017

Publications

  • L Kennedy and H Francis, “Defining the relationship between farsenoid X receptor, hepatitis B virus X protein and HCC: It’s complicated” Hepatology, accepted 11/23/16

Presentations

  • L Hargrove, L Kennedy, J Owens, H Francis. Cholestatic-induced biliary proliferation and fibrosis are decreased in mice lacking mast cells: an innovative study using c-kit knockout mice. Hepatology 64:341, 2016. Poster of Distinction, American Association of the Study of Liver Disease, Boston, MA
  • J Demieville, L Hargrove, L Kennedy, V Jarido, H Francis. Knockout of the HDC/histamine axis and reduction of mast cell number/function rescues Mdr2-/- mice from PSC-related biliary proliferation and fibrosis. Hepatology 64:181, 2016 Presidential Podium Presentation, American Association of the Study of Liver Disease, Boston, MA
  • K Sato, N Wu, J Venter, K McDaniel, T Zhou, S Glaser, G Alpini, and F Meng. Cholangiocytes treated with lipopolysaccharide cause inflammatory reactions in other cholangiocytes by secretion of extracellular vesicles.  Oral presentation, AASLD meeting, November 2016.
  • C Hall, L Ehrlich, J Venter, A O’Brien, F Meng, G Alpini, S Glaser, and T Lairmore. Inhibition of miR-24-1 Increases Menin Expression and Promotes Hepatic Fibrosis in Mdr2-/-  Poster presentation, AASLD meeting, November 2016.
  • N Wu, J Venter, L Kennedy, F Meng, H Francis, T Zhou, S Glaser, and G Alpini. Knockout of the secretin receptor (SR) reduces biliary proliferation, lipoapoptosis, cellular senescence and liver fibrosis in high-fat diet-induced obese mice.  Oral presentation, AASLD meeting, November 2016.
  • L Ehrlich, C Hall, J Venter, F Meng, T Lairmore, G Alpini, and S Glaser. Inhibition of miR-24 decreases cholangiocarcinoma growth both in vitro and in vivo in athymic mice through enhanced menin expression. Oral presentation, AASLD meeting, November 2016.
  • K Kyritsi, N Wu, P Invernizzi, J Venter, T Zhou, K Sato, F Bernuzzi, K McDaniel, P Onori, A Franchitto, E Gaudio, H Francis, S Glaser, F Meng, and G Alpini. Gonadotropin-releasing hormone (GnRH) contributes to liver fibrosis in primary sclerosing cholangitis (PSC) through enhanced epithelial-mesenchymal transition (EMT) in small but increased senescence in large cholangiocytes.  Poster presentation, AASLD meeting, November 2016.
  • N Wu, F Meng, P Invernizzi, J Venter, F Bernuzzi, D Alvaro, P Onori, A Franchitto, T Zhou, H Francis, K Kyritsi, R Mancinelli, E Gaudio, G Alpini, and S Glaser. The melatonin/MT1/miR-200b axis regulates biliary senescence and liver fibrosis in the Mdr2-/- mouse model of primary sclerosing cholangitis (PSC): novel implications for the management of PSC.  Poster presentation, AASLD meeting, November 2016.
  • S DeMorrow, S Khan, S Grant, G Frampton, M McMillin. TGFβ1 signaling promotes acetaminophen-induced hepatotoxicity in mice.  Oral presentation, American Association for the Study of Liver Diseases.  Boston, MA.  November 2016.
  • M McMillin, S Grant, G Frampton, S DeMorrow. Liver-derived TGFβ1 contributes to the neurological decline associated with acute liver failure.  Poster presentation, American Association for the Study of Liver Diseases.  Boston, MA.  November 2016.
  • M McMillin, S Grant, G Frampton, F Meng, S DeMorrow. Aberrant TGFβ1 signaling decreases the expression of acid labile subunit thereby decreasing the stability of IGF-1 during acute liver failure.  AASLD Presidential Poster of Distinction presentation, American Association for the Study of Liver Diseases.  Boston, MA.  November 2016.

 

Professional Activities and Appointments

  • Gianfranco Alpini – Invited lecture “Vascular factors, angiogenesis and liver diseases” at the 1st Chinese Microcirculation Week, Peking University Health Science Center, November 2016.
  • Gianfranco Alpini – Invited lecture “The Editor’s point-of-view” Southern Medical University Shenzhen Hospital, Shenzhen, China.
  • Gianfranco Alpini – Chaired a plenary session entitled “Exosomes and cardiovascular diseases” at the 1st Chinese Microcirculation Week, Peking University Health Science Center, November 2016.
  • Gianfranco Alpini – Attended the Hepatobiliary Pathobiology and Toxicology, Special Emphasis Panel/Scientific Review Group 2017/01 ZRG1 DKUS-L (04) M meeting